[HTML][HTML] Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates …

J Dixelius, T Makinen, M Wirzenius… - Journal of Biological …, 2003 - ASBMB
Vascular endothelial growth factors (VEGFs) regulate the development and growth of the
blood and lymphatic vascular systems. Of the three VEGF receptors (VEGFR), VEGFR-1 and-
2 are expressed on blood vessels; VEGFR-2 is found also on lymphatic vessels. VEGFR-3 is
expressed mainly on lymphatic vessels but it is also up-regulated in tumor angiogenesis.
Although VEGFR-3 is essential for proper lymphatic development, its signal transduction
mechanisms are still incompletely understood. Trans-phosphorylation of activated …