Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy
BA Croy, AA Ashkar, RA Foster, JP DiSanto… - Journal of reproductive …, 1997 - Elsevier
Maternal lymphocytes having a large and granulated morphology accumulate at healthy
implantation sites in normal mice. Insight into the functions of these cells has come from a
previous study of two independent lines of mice deficient in natural killer (NK) cells. In
pregnant Tgϵ26 mice, vascular pathology was found that led to the major complications of
either fetal death or intrauterine growth retardation. In pregnant p56lck null× IL-2Rβ null
mice, extensive distension of the decidua was observed that separated the placenta from the …
implantation sites in normal mice. Insight into the functions of these cells has come from a
previous study of two independent lines of mice deficient in natural killer (NK) cells. In
pregnant Tgϵ26 mice, vascular pathology was found that led to the major complications of
either fetal death or intrauterine growth retardation. In pregnant p56lck null× IL-2Rβ null
mice, extensive distension of the decidua was observed that separated the placenta from the …