Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma
Background The 3-gene signature of periostin, chloride channel accessory 1 (CLCA1), and
Serpin β2 (SERPINB2) in airway epithelial brushings is used to classify asthma into TH 2-
high and TH 2-low endotypes. Little is known about the utility of gene profiling in sputum as
a molecular phenotyping method. Objective We sought to determine whether gene profiling
in sputum cells can identify TH 2-high and TH 2-low subtypes of asthma. Methods In induced
sputum cell pellets from 37 asthmatic patients and 15 healthy control subjects, PCR was …
Serpin β2 (SERPINB2) in airway epithelial brushings is used to classify asthma into TH 2-
high and TH 2-low endotypes. Little is known about the utility of gene profiling in sputum as
a molecular phenotyping method. Objective We sought to determine whether gene profiling
in sputum cells can identify TH 2-high and TH 2-low subtypes of asthma. Methods In induced
sputum cell pellets from 37 asthmatic patients and 15 healthy control subjects, PCR was …