[HTML][HTML] Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis
HL Osborn-Heaford, AJ Ryan, S Murthy… - Journal of Biological …, 2012 - ASBMB
The generation of reactive oxygen species, particularly H 2 O 2, from alveolar macrophages
is causally related to the development of pulmonary fibrosis. Rac1, a small GTPase, is
known to increase mitochondrial H 2 O 2 generation in macrophages; however, the
mechanism by which this occurs is not known. This study shows that Rac1 is localized in the
mitochondria of alveolar macrophages from asbestosis patients, and mitochondrial import
requires the C-terminal cysteine of Rac1 (Cys-189), which is post-translationally modified by …
is causally related to the development of pulmonary fibrosis. Rac1, a small GTPase, is
known to increase mitochondrial H 2 O 2 generation in macrophages; however, the
mechanism by which this occurs is not known. This study shows that Rac1 is localized in the
mitochondria of alveolar macrophages from asbestosis patients, and mitochondrial import
requires the C-terminal cysteine of Rac1 (Cys-189), which is post-translationally modified by …