[HTML][HTML] Inducible nitric-oxide synthase is an important contributor to prolonged protective effects of ischemic preconditioning in the mouse kidney
KM Park, JY Byun, C Kramers, JI Kim, PL Huang… - Journal of Biological …, 2003 - ASBMB
Ischemic preconditioning renders the mouse kidney resistant to subsequent ischemia.
Understanding the mechanisms responsible for ischemic preconditioning is important for
formulating therapeutic strategies aimed at mimicking protective mechanisms. We report that
the resistance afforded by 30 min of bilateral kidney ischemia persists for 12 weeks after
preconditioning. The protection is reflected by improved postischemic renal function,
reduced leukocyte infiltration, reduced postischemic disruption of the actin cytoskeleton, and …
Understanding the mechanisms responsible for ischemic preconditioning is important for
formulating therapeutic strategies aimed at mimicking protective mechanisms. We report that
the resistance afforded by 30 min of bilateral kidney ischemia persists for 12 weeks after
preconditioning. The protection is reflected by improved postischemic renal function,
reduced leukocyte infiltration, reduced postischemic disruption of the actin cytoskeleton, and …