[HTML][HTML] MicroRNA-205 maintains T cell development following stress by regulating forkhead box N1 and selected chemokines

AR Hoover, I Dozmorov, J MacLeod, Q Du… - Journal of Biological …, 2016 - ASBMB
The thymus, an organ responsible for T cell development, is one of the more stress-sensitive
tissues in the body. Stress, in the form of infections, radiation exposure, and steroids, impairs
thymic epithelial cell (TEC) functions and induces the programmed cell death of immature
thymocytes. MicroRNAs are small noncoding RNAs involved in tissue repair and
homeostasis, with several supporting T cell development. We report that miR-205, an
epithelial-specific miR, maintains thymopoiesis following inflammatory perturbations. Thus …