[HTML][HTML] Alteration of developmental and pathological retinal angiogenesis in angptl4-deficient mice

EG Perdiguero, A Galaup, M Durand, J Teillon… - Journal of Biological …, 2011 - ASBMB
Proper vessel maturation, remodeling of endothelial junctions, and recruitment of
perivascular cells is crucial for establishing and maintaining vessel functions. In proliferative
retinopathies, hypoxia-induced angiogenesis is associated with disruption of the vascular
barrier, edema, and vision loss. Therefore, identifying factors that regulate vascular
maturation is critical to target pathological angiogenesis. Given the conflicting role of
angiopoietin-like-4 (ANGPTL4) reported in the current literature using gain of function …