Vascular endothelial growth factor
N Ferrara - Arteriosclerosis, thrombosis, and vascular biology, 2009 - Am Heart Assoc
Arteriosclerosis, thrombosis, and vascular biology, 2009•Am Heart Assoc
Vascular endothelial growth factor (VEGF, VEGF-A) is a major regulator of physiological and
pathological angiogenesis. Several VEGF inhibitors have been approved by the FDA for the
treatment of advanced cancer and neovascular age-related macular degeneration. This brief
review provides a historic account of the challenges associated with the discovery of VEGF
and the early steps in elucidating the role of this molecule in the regulation of angiogenesis.
pathological angiogenesis. Several VEGF inhibitors have been approved by the FDA for the
treatment of advanced cancer and neovascular age-related macular degeneration. This brief
review provides a historic account of the challenges associated with the discovery of VEGF
and the early steps in elucidating the role of this molecule in the regulation of angiogenesis.
Vascular endothelial growth factor (VEGF, VEGF-A) is a major regulator of physiological and pathological angiogenesis. Several VEGF inhibitors have been approved by the FDA for the treatment of advanced cancer and neovascular age-related macular degeneration. This brief review provides a historic account of the challenges associated with the discovery of VEGF and the early steps in elucidating the role of this molecule in the regulation of angiogenesis.
Am Heart Assoc