Increase in vascular permeability occurs under many physiological conditions such as
wound repair, inflammation, and thrombotic reactions and is central in diverse human
pathologies, including tumor-induced angiogenesis, ocular diseases, and septic shock.
Thrombin is a pro-coagulant serine protease, which causes the local loss of endothelial
barrier integrity thereby enabling the rapid extravasation of plasma proteins and the local
formation of fibrin-containing clots. Available information suggests that thrombin induces …