[HTML][HTML] Molecular cloning, expression, and characterization of angiopoietin-related protein: angiopoietin-related protein induces endothelial cell sprouting

I Kim, SO Moon, KN Koh, H Kim, CS Uhm… - Journal of Biological …, 1999 - ASBMB
Using degenerate polymerase chain reaction, we isolated a cDNA encoding a novel 493-
amino acid protein from human and mouse adult heart cDNAs and have designated it
angiopoietin-related protein-2 (ARP2). The NH 2-terminal and COOH-terminal portions of
ARP2 contain the characteristic coiled-coil domain and fibrinogen-like domain that are
conserved in angiopoietins. ARP2 has two consensus glycosylation sites and a highly
hydrophobic region at the NH 2 terminus that is typical of a secretory signal sequence …