Initiation of antiretroviral therapy before detection of colonic infiltration by HIV reduces viral reservoirs, inflammation and immune activation
TA Crowell, JLK Fletcher, I Sereti… - African Journal of …, 2016 - journals.lww.com
Introduction: Colonic infiltration by HIV occurs soon after infection, establishing a persistent
viral reservoir and a barrier to cure. We investigated virologic and immunologic correlates of
detectable colonic HIV RNA during acute HIV infection (AHI) and their response to
antiretroviral treatment (ART). Methods: From 49,458 samples screened for HIV, 74
participants were enrolled during AHI and 41 consented to optional sigmoidoscopy, HIV
RNA was categorized as detectable (] 50 copies/mg) or undetectable in homogenized colon …
viral reservoir and a barrier to cure. We investigated virologic and immunologic correlates of
detectable colonic HIV RNA during acute HIV infection (AHI) and their response to
antiretroviral treatment (ART). Methods: From 49,458 samples screened for HIV, 74
participants were enrolled during AHI and 41 consented to optional sigmoidoscopy, HIV
RNA was categorized as detectable (] 50 copies/mg) or undetectable in homogenized colon …