Perspectives on human immunodeficiency virus (HIV) cure: HIV persistence in tissue

EA Boritz, DC Douek - The Journal of Infectious Diseases, 2017 - academic.oup.com
EA Boritz, DC Douek
The Journal of Infectious Diseases, 2017academic.oup.com
The uneven anatomic distribution of cell subsets that harbor human immunodeficiency virus
(HIV) during antiretroviral therapy (ART) complicates investigation of the barriers to HIV cure.
Here we propose that while previous studies done largely in blood cells have led to
important investigations into HIV latency, other important mechanisms of HIV persistence
during ART may not be readily apparent in the bloodstream. We specifically consider as an
example the question of ongoing HIV replication during ART. We discuss how growing …
Abstract
The uneven anatomic distribution of cell subsets that harbor human immunodeficiency virus (HIV) during antiretroviral therapy (ART) complicates investigation of the barriers to HIV cure. Here we propose that while previous studies done largely in blood cells have led to important investigations into HIV latency, other important mechanisms of HIV persistence during ART may not be readily apparent in the bloodstream. We specifically consider as an example the question of ongoing HIV replication during ART. We discuss how growing understanding of key anatomic sanctuaries for the virus can inform future experiments aimed at further clarifying this issue.
Oxford University Press