[HTML][HTML] Multiplexed Fc array for evaluation of antigen-specific antibody effector profiles

EP Brown, KG Dowell, AW Boesch… - Journal of …, 2017 - Elsevier
Antibodies are widely considered to be a frequent primary and often mechanistic correlate of
protection of approved vaccines; thus evaluating the antibody response is of critical
importance in attempting to understand and predict the efficacy of novel vaccine candidates.
Historically, antibody responses have been analyzed by determining the titer of the humoral
response using measurements such as an ELISA, neutralization, or agglutination assays. In
the simplest case, sufficiently high titers of antibody against vaccine antigen (s) are sufficient …