[HTML][HTML] The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

T Kawai, S Akira - Nature immunology, 2010 - nature.com
T Kawai, S Akira
Nature immunology, 2010nature.com
The discovery of Toll-like receptors (TLRs) as components that recognize conserved
structures in pathogens has greatly advanced understanding of how the body senses
pathogen invasion, triggers innate immune responses and primes antigen-specific adaptive
immunity. Although TLRs are critical for host defense, it has become apparent that loss of
negative regulation of TLR signaling, as well as recognition of self molecules by TLRs, are
strongly associated with the pathogenesis of inflammatory and autoimmune diseases …
Abstract
The discovery of Toll-like receptors (TLRs) as components that recognize conserved structures in pathogens has greatly advanced understanding of how the body senses pathogen invasion, triggers innate immune responses and primes antigen-specific adaptive immunity. Although TLRs are critical for host defense, it has become apparent that loss of negative regulation of TLR signaling, as well as recognition of self molecules by TLRs, are strongly associated with the pathogenesis of inflammatory and autoimmune diseases. Furthermore, it is now clear that the interaction between TLRs and recently identified cytosolic innate immune sensors is crucial for mounting effective immune responses. Here we describe the recent advances that have been made by research into the role of TLR biology in host defense and disease.
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