[HTML][HTML] Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin
MM Monick, TO Yarovinsky, LS Powers… - Journal of Biological …, 2003 - ASBMB
Airway epithelial cells are unresponsive to endotoxin (lipopolysaccharide (LPS)) exposure
under normal conditions. This study demonstrates that respiratory syncytial virus (RSV)
infection results in increased sensitivity to this environmental exposure. Infection with RSV
results in increased expression of Toll-like receptor (TLR) 4 mRNA, protein, and increased
TLR4 membrane localization. This permits significantly enhanced LPS binding to the
epithelial monolayer that is blocked by disruption of the Golgi. The increased TLR4 results in …
under normal conditions. This study demonstrates that respiratory syncytial virus (RSV)
infection results in increased sensitivity to this environmental exposure. Infection with RSV
results in increased expression of Toll-like receptor (TLR) 4 mRNA, protein, and increased
TLR4 membrane localization. This permits significantly enhanced LPS binding to the
epithelial monolayer that is blocked by disruption of the Golgi. The increased TLR4 results in …