A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis
G D'haens, WJ Sandborn, BG Feagan… - …, 2007 - gastrojournal.org
Ulcerative colitis (UC) is a common gastrointestinal disorder in adults. Recent advances in
pathophysiology, immunology, and pharmaceutical science have resulted in a large number
of medications including biologic agents with potential application to the treatment of UC.
Clinical development of these drugs requires well-controlled trials evaluating safety and
efficacy. The first randomized controlled trial in UC dates back to 1955 when cortisone was
shown to be effective for the treatment of active disease. Further experience in clinical trial …
pathophysiology, immunology, and pharmaceutical science have resulted in a large number
of medications including biologic agents with potential application to the treatment of UC.
Clinical development of these drugs requires well-controlled trials evaluating safety and
efficacy. The first randomized controlled trial in UC dates back to 1955 when cortisone was
shown to be effective for the treatment of active disease. Further experience in clinical trial …