Adipose tissue secretes protein factors that have systemic actions on cardiovascular tissues.
Previous studies have shown that ablation of the adipocyte-secreted protein adiponectin
leads to endothelial dysfunction, whereas its overexpression promotes wound healing.
However, the receptor (s) mediating the protective effects of adiponectin on the vasculature
is not known. Here we examined the role of membrane protein T-cadherin, which localizes
adiponectin to the vascular endothelium, in the revascularization response to chronic …