[HTML][HTML] Adipocyte-specific disruption of fat-specific protein 27 causes hepatosteatosis and insulin resistance in high-fat diet-fed mice
N Tanaka, S Takahashi, T Matsubara, C Jiang… - Journal of Biological …, 2015 - ASBMB
White adipose tissue (WAT) functions as an energy reservoir where excess circulating fatty
acids are transported to WAT, converted to triglycerides, and stored as unilocular lipid
droplets. Fat-specific protein 27 (FSP27, CIDEC in humans) is a lipid-coating protein highly
expressed in mature white adipocytes that contributes to unilocular lipid droplet formation.
However, the influence of FSP27 in adipose tissue on whole-body energy homeostasis
remains unclear. Mice with adipocyte-specific disruption of the Fsp27 gene (Fsp27 ΔAd) …
acids are transported to WAT, converted to triglycerides, and stored as unilocular lipid
droplets. Fat-specific protein 27 (FSP27, CIDEC in humans) is a lipid-coating protein highly
expressed in mature white adipocytes that contributes to unilocular lipid droplet formation.
However, the influence of FSP27 in adipose tissue on whole-body energy homeostasis
remains unclear. Mice with adipocyte-specific disruption of the Fsp27 gene (Fsp27 ΔAd) …