Mutations in the 1-acylglycerol-3-phosphate-O-acyltransferase 2 (AGPAT2) gene have been
identified in individuals affected with congenital generalized lipodystrophy (CGL). AGPAT2
catalyzes acylation of lysophosphatidic acid to phosphatidic acid, a precursor for both
triacylglycerol (TAG) and phospholipid synthesis. Recent studies suggest that reduced
AGPAT2 enzymatic activity may underlie the CGL clinical phenotype. To gain insight into
how altered AGPAT2 activity causes lipodystrophy, we examined the effect of knockdown of …