[HTML][HTML] Immune cell interplay in colorectal cancer prognosis
SE Norton, KA Ward-Hartstonge… - World journal of …, 2015 - ncbi.nlm.nih.gov
SE Norton, KA Ward-Hartstonge, ES Taylor, RA Kemp
World journal of gastrointestinal oncology, 2015•ncbi.nlm.nih.govThe immune response to colorectal cancer has proven to be a reliable measure of patient
outcome in several studies. However, the complexity of the immune response in this disease
is not well understood, particularly the interactions between tumour-associated cells and
cells of the innate and adaptive immune system. This review will discuss the relationship
between cancer associated fibroblasts and macrophages, as well as between macrophages
and T cells, and demonstrate how each population may support or prevent tumour growth in …
outcome in several studies. However, the complexity of the immune response in this disease
is not well understood, particularly the interactions between tumour-associated cells and
cells of the innate and adaptive immune system. This review will discuss the relationship
between cancer associated fibroblasts and macrophages, as well as between macrophages
and T cells, and demonstrate how each population may support or prevent tumour growth in …
Abstract
The immune response to colorectal cancer has proven to be a reliable measure of patient outcome in several studies. However, the complexity of the immune response in this disease is not well understood, particularly the interactions between tumour-associated cells and cells of the innate and adaptive immune system. This review will discuss the relationship between cancer associated fibroblasts and macrophages, as well as between macrophages and T cells, and demonstrate how each population may support or prevent tumour growth in a different immune environment.
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