Transdifferentiation of cultured human prostate cancer cells to a neuroendocrine cell phenotype in a hormone-depleted medium
R Shen, T Dorai, M Szaboles, AE Katz… - … Oncology: Seminars and …, 1997 - Elsevier
Neuroendocrine (NE) cells are enigmatically found in association with human prostate
cancers and their numbers are reported to increase in advanced and hormoneresistant
tumors. The origin of this cell type and the reason for their appearance in prostate tumors
remains unresolved. Previously, Bang et al.(Proc Natl Acad Sci USA 1994; 91: 5330)
reported that dibutyryl adenosine 3′, 5′-cyclic phosphate (db-cAMP), an agent that
upregulates intracellular cAMP, was able to induce a NE cell-like phenotype of cultured …
cancers and their numbers are reported to increase in advanced and hormoneresistant
tumors. The origin of this cell type and the reason for their appearance in prostate tumors
remains unresolved. Previously, Bang et al.(Proc Natl Acad Sci USA 1994; 91: 5330)
reported that dibutyryl adenosine 3′, 5′-cyclic phosphate (db-cAMP), an agent that
upregulates intracellular cAMP, was able to induce a NE cell-like phenotype of cultured …