Oxalate, inflammasome, and progression of kidney disease
T Ermer, KU Eckardt, PS Aronson… - Current opinion in …, 2016 - journals.lww.com
Current opinion in nephrology and hypertension, 2016•journals.lww.com
The findings reviewed in this article expand our understanding of the relevance of elevated
plasma oxalate levels leading to inflammasome activation. We propose that inhibiting
oxalate-induced inflammasome activation, or lowering plasma oxalate, may prevent or
mitigate progressive renal damage in CKD, and warrants clinical trials.
plasma oxalate levels leading to inflammasome activation. We propose that inhibiting
oxalate-induced inflammasome activation, or lowering plasma oxalate, may prevent or
mitigate progressive renal damage in CKD, and warrants clinical trials.
Summary
The findings reviewed in this article expand our understanding of the relevance of elevated plasma oxalate levels leading to inflammasome activation. We propose that inhibiting oxalate-induced inflammasome activation, or lowering plasma oxalate, may prevent or mitigate progressive renal damage in CKD, and warrants clinical trials.
Lippincott Williams & Wilkins