The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation
JJ Talbot, X Song, X Wang, MM Rinschen… - Journal of the …, 2014 - journals.lww.com
Abstract Polycystin-1 (PC1) mutations result in proliferative renal cyst growth and
progression to renal failure in autosomal dominant polycystic kidney disease (ADPKD). The
transcription factor STAT3 (signal transducer and activator of transcription 3) was shown to
be activated in cyst-lining cells in ADPKD and PKD mouse models and may drive renal cyst
growth, but the mechanisms leading to persistent STAT3 activation are unknown. A
proteolytic fragment of PC1 corresponding to the cytoplasmic tail, PC1-p30, is …
progression to renal failure in autosomal dominant polycystic kidney disease (ADPKD). The
transcription factor STAT3 (signal transducer and activator of transcription 3) was shown to
be activated in cyst-lining cells in ADPKD and PKD mouse models and may drive renal cyst
growth, but the mechanisms leading to persistent STAT3 activation are unknown. A
proteolytic fragment of PC1 corresponding to the cytoplasmic tail, PC1-p30, is …
