Mcp1 promotes macrophage-dependent cyst expansion in autosomal dominant polycystic kidney disease
MF Cassini, VR Kakade, E Kurtz… - Journal of the …, 2018 - journals.lww.com
Background In patients with autosomal dominant polycystic kidney disease (ADPKD), most
of whom have a mutation in PKD1 or PKD2, abnormally large numbers of macrophages
accumulate around kidney cysts and promote their growth. Research by us and others has
suggested that monocyte chemoattractant protein-1 (Mcp1) may be a signal for macrophage-
mediated cyst growth. Methods To define the role of Mcp1 and macrophages in promoting
cyst growth, we used mice with inducible knockout of Pkd1 alone (single knockout) or …
of whom have a mutation in PKD1 or PKD2, abnormally large numbers of macrophages
accumulate around kidney cysts and promote their growth. Research by us and others has
suggested that monocyte chemoattractant protein-1 (Mcp1) may be a signal for macrophage-
mediated cyst growth. Methods To define the role of Mcp1 and macrophages in promoting
cyst growth, we used mice with inducible knockout of Pkd1 alone (single knockout) or …