Retention of calcium oxalate crystals in renal tubules

SR Khan, RL Hackett - Scanning microscopy, 1991 - digitalcommons.usu.edu
SR Khan, RL Hackett
Scanning microscopy, 1991digitalcommons.usu.edu
Crystal retention within the renal tubules is essential for nephrolithiasis and the development
of urinary stone disease. We studied the mechanisms involved in this process by inducing
calcium oxalate crystal deposition within the rat renal tubules and examining them using
various microscopic techniques. Crystals appeared to be retained either by attachment to
the tubular epithelium or by aggregating with other crystals thus becoming large enough to
be retained by their collective size.
Abstract
Crystal retention within the renal tubules is essential for nephrolithiasis and the development of urinary stone disease. We studied the mechanisms involved in this process by inducing calcium oxalate crystal deposition within the rat renal tubules and examining them using various microscopic techniques. Crystals appeared to be retained either by attachment to the tubular epithelium or by aggregating with other crystals thus becoming large enough to be retained by their collective size.
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