Potassium citrate/citric acid intake improves renal function in rats with polycystic kidney disease.
GA Tanner - Journal of the American Society of Nephrology, 1998 - journals.lww.com
Polycystic kidney disease (PKD) has been shown to be exacerbated by acidosis or a low
potassium intake, and there is evidence that administration of alkali might have a beneficial
effect. This study determined whether ingestion of potassium citrate and citric acid would
ameliorate PKD. Healthy normal and heterozygous littermate Han: SPRD rats with
autosomal dominant PKD were provided with either tap water or 55 mM K3citrate/67 mM
citric acid solution (KCitr) to drink starting at the age of 1 mo. Renal clearance …
potassium intake, and there is evidence that administration of alkali might have a beneficial
effect. This study determined whether ingestion of potassium citrate and citric acid would
ameliorate PKD. Healthy normal and heterozygous littermate Han: SPRD rats with
autosomal dominant PKD were provided with either tap water or 55 mM K3citrate/67 mM
citric acid solution (KCitr) to drink starting at the age of 1 mo. Renal clearance …