[HTML][HTML] NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation
MS Hipp, S Raasi, M Groettrup, G Schmidtke - Journal of Biological …, 2004 - ASBMB
FAT10 is an interferon-γ-inducible ubiquitin-like protein that consists of two ubiquitin-like
domains. FAT10 bears a diglycine motif at its C terminus that can form isopeptide bonds to
so far unidentified target proteins. Recently we found that FAT10 and its conjugates are
rapidly degraded by the proteasome and that the N-terminal fusion of FAT10 to a long lived
protein markedly reduces its half-life. FAT10 may hence direct target proteins to the
proteasome for degradation. In this study we report a new interaction partner of FAT10 that …
domains. FAT10 bears a diglycine motif at its C terminus that can form isopeptide bonds to
so far unidentified target proteins. Recently we found that FAT10 and its conjugates are
rapidly degraded by the proteasome and that the N-terminal fusion of FAT10 to a long lived
protein markedly reduces its half-life. FAT10 may hence direct target proteins to the
proteasome for degradation. In this study we report a new interaction partner of FAT10 that …