[PDF][PDF] TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection

NV Serbina, TP Salazar-Mather, CA Biron, WA Kuziel… - Immunity, 2003 - cell.com
NV Serbina, TP Salazar-Mather, CA Biron, WA Kuziel, EG Pamer
Immunity, 2003cell.com
Dendritic cells (DCs) present microbial antigens to T cells and provide inflammatory signals
that modulate T cell differentiation. While the role of DCs in adaptive immunity is well
established, their involvement in innate immune defenses is less well defined. We have
identified a TNF/iNOS-producing (Tip)-DC subset in spleens of Listeria monocytogenes-
infected mice that is absent from CCR2-deficient mice. The absence of Tip-DCs results in
profound TNF and iNOS deficiencies and an inability to clear primary bacterial infection …
Abstract
Dendritic cells (DCs) present microbial antigens to T cells and provide inflammatory signals that modulate T cell differentiation. While the role of DCs in adaptive immunity is well established, their involvement in innate immune defenses is less well defined. We have identified a TNF/iNOS-producing (Tip)-DC subset in spleens of Listeria monocytogenes-infected mice that is absent from CCR2-deficient mice. The absence of Tip-DCs results in profound TNF and iNOS deficiencies and an inability to clear primary bacterial infection. CD8 and CD4 T cell responses to L. monocytogenes antigens are preserved in CCR2-deficient mice, indicating that Tip-DCs are not essential for T cell priming. Tip-DCs, as the predominant source of TNF and iNOS during L. monocytogenes infection, orchestrate and mediate innate immune defense against this intracellular bacterial pathogen.
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