Human interleukin 17–producing cells originate from a CD161+CD4+ T cell precursor
L Cosmi, R De Palma, V Santarlasci, L Maggi… - The Journal of …, 2008 - rupress.org
L Cosmi, R De Palma, V Santarlasci, L Maggi, M Capone, F Frosali, G Rodolico, V Querci…
The Journal of experimental medicine, 2008•rupress.orgWe demonstrate that CD161 is a highly up-regulated gene in human interleukin (IL) 17 T
helper cell (Th17) clones and that all IL-17–producing cells are contained in the CD161+
fraction of CD4+ T cells present in the circulation or in inflamed tissues, although they are
not CD1-restricted natural killer T cells. More importantly, we show that all IL-17–producing
cells originate from CD161+ naive CD4+ T cells of umbilical cord blood, as well as of the
postnatal thymus, in response to the combined activity of IL-1β and IL-23. These findings …
helper cell (Th17) clones and that all IL-17–producing cells are contained in the CD161+
fraction of CD4+ T cells present in the circulation or in inflamed tissues, although they are
not CD1-restricted natural killer T cells. More importantly, we show that all IL-17–producing
cells originate from CD161+ naive CD4+ T cells of umbilical cord blood, as well as of the
postnatal thymus, in response to the combined activity of IL-1β and IL-23. These findings …
We demonstrate that CD161 is a highly up-regulated gene in human interleukin (IL) 17 T helper cell (Th17) clones and that all IL-17–producing cells are contained in the CD161+ fraction of CD4+ T cells present in the circulation or in inflamed tissues, although they are not CD1-restricted natural killer T cells. More importantly, we show that all IL-17–producing cells originate from CD161+ naive CD4+ T cells of umbilical cord blood, as well as of the postnatal thymus, in response to the combined activity of IL-1β and IL-23. These findings implicate CD161 as a novel surface marker for human Th17 cells and demonstrate the exclusive origin of these cells from a CD161+CD4+ T cell progenitor.
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