[CITATION][C] Rapamycin: In Vitro Profile of a New Immunosuppressive Macrolide.

SN Sehgal, CC Bansbach - Annals of the New York Academy of …, 1993 - Wiley Online Library
SN Sehgal, CC Bansbach
Annals of the New York Academy of Sciences, 1993Wiley Online Library
Rapamycin (RAPA)(FIG. 1) is a macrocyclic triene antibiotic produced by St~ eptom9ces
&roscupixs, an actinomycete that was isolated from a soil sample collected from the Vai
Atore region of Easter Island.'J The name, rapamycin, is derived from Rapa Nui, the native
name for Easter Island. Originally isolated as an antifungal agent, RAPA is extremely potent
against several clinical isolates of Cad& (MIC 0.02-0.2~ g/ml).~ In addition, RAPA was found
to be active in several murine tumor models (B16 melanocarcinoma, colon 26 tumor, EM …
Rapamycin (RAPA)(FIG. 1) is a macrocyclic triene antibiotic produced by St~ eptom9ces &roscupixs, an actinomycete that was isolated from a soil sample collected from the Vai Atore region of Easter Island.'J The name, rapamycin, is derived from Rapa Nui, the native name for Easter Island. Originally isolated as an antifungal agent, RAPA is extremely potent against several clinical isolates of Cad& (MIC 0.02-0.2~ g/ml).~ In addition, RAPA was found to be active in several murine tumor models (B16 melanocarcinoma, colon 26 tumor, EM ependymoblastoma, and CD8F1 mammary and colon 38 solid tum~ rs).~.~ The immunosuppressive activity of RAPA in rat models of adjuvant arthritis and experimental allergic encephalomyelitis was reported by our laboratory in 1977.6
Recent studies on the in vivo effects of RAPA have demonstrated that it is a potent immunosuppressant which exhibits remarkable antirejection activity in animal models of organ transplantation and ameliorates experimental T cell-mediated autoimmune disorder^.^ The in vim studies of RAPA in experimental models of allograf? rejection and autoimmune diseases are described in detail in other papers in this volume. In this report we present the in viwo immunologic properties of RAPA that form a rationale for the in vim activity of this novel immunosuppressant.
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