[HTML][HTML] Transmembrane protein 16A (TMEM16A) is a Ca2+-regulated Cl–secretory channel in mouse airways

JR Rock, WK O'Neal, SE Gabriel, SH Randell… - Journal of Biological …, 2009 - ASBMB
For almost two decades, it has been postulated that calcium-activated Cl–channels (CaCCs)
play a role in airway epithelial Cl–secretion, but until recently, the molecular identity of the
airway CaCC (s) was unknown. Recent studies have unequivocally identified TMEM16A as
a glandular epithelial CaCC. We have studied the airway bioelectrics of neonatal mice
homozygous for a null allele of Tmem16a (Tmem16a–/–) to investigate the role of this
channel in Cl–secretion in airway surface epithelium. When compared with wild-type …