[HTML][HTML] The ER stress transducer IRE1β is required for airway epithelial mucin production
MB Martino, L Jones, B Brighton, C Ehre, L Abdulah… - Mucosal …, 2013 - Elsevier
Inflammation of human bronchial epithelia (HBE) activates the endoplasmic reticulum (ER)
stress transducer inositol-requiring enzyme 1 (IRE1) α, resulting in IRE1α-mediated cytokine
production. Previous studies demonstrated ubiquitous expression of IRE1α and gut-
restricted expression of IRE1β. We found that IRE1β is also expressed in HBE, is absent in
human alveolar cells, and is upregulated in cystic fibrosis and asthmatic HBE. Studies with
Ire1β−/− mice and Calu-3 airway epithelia exhibiting IRE1β knockdown or overexpression …
stress transducer inositol-requiring enzyme 1 (IRE1) α, resulting in IRE1α-mediated cytokine
production. Previous studies demonstrated ubiquitous expression of IRE1α and gut-
restricted expression of IRE1β. We found that IRE1β is also expressed in HBE, is absent in
human alveolar cells, and is upregulated in cystic fibrosis and asthmatic HBE. Studies with
Ire1β−/− mice and Calu-3 airway epithelia exhibiting IRE1β knockdown or overexpression …