[HTML][HTML] Normal and cystic fibrosis airway surface liquid homeostasis: the effects of phasic shear stress and viral infections
Mammalian airways normally regulate the volume of a thin liquid layer, the periciliary liquid
(PCL), to facilitate the mucus clearance component of lung defense. Studies under standard
(static) culture conditions revealed that normal airway epithelia possess an adenosine-
regulated pathway that blends Na+ absorption and Cl-secretion to optimize PCL volume. In
cystic fibrosis (CF), the absence of CF transmembrane conductance regulator results in a
failure of adenosine regulation of PCL volume, which is predicted to initiate mucus stasis …
(PCL), to facilitate the mucus clearance component of lung defense. Studies under standard
(static) culture conditions revealed that normal airway epithelia possess an adenosine-
regulated pathway that blends Na+ absorption and Cl-secretion to optimize PCL volume. In
cystic fibrosis (CF), the absence of CF transmembrane conductance regulator results in a
failure of adenosine regulation of PCL volume, which is predicted to initiate mucus stasis …