[HTML][HTML] Feed-forward signaling by membrane-bound ligand receptor circuit: the case of NOTCH DELTA-like 4 ligand in endothelial cells
V Caolo, NMS Van Den Akker, S Verbruggen… - Journal of Biological …, 2010 - ASBMB
The DELTA like-4 ligand (DLL4) belongs to the highly conserved NOTCH family and is
specifically expressed in the endothelium. DLL4 regulates crucial processes in vascular
growth, including endothelial cell (EC) sprouting and arterial specification. Its expression is
increased by VEGF-A. In the present study, we show that VEGF-induced DLL4 expression
depends on NOTCH activation. VEGF-induced DLL4 expression was prevented by the
blockage of NOTCH signaling with γ-secretase or ADAM inhibitors in human cardiac …
specifically expressed in the endothelium. DLL4 regulates crucial processes in vascular
growth, including endothelial cell (EC) sprouting and arterial specification. Its expression is
increased by VEGF-A. In the present study, we show that VEGF-induced DLL4 expression
depends on NOTCH activation. VEGF-induced DLL4 expression was prevented by the
blockage of NOTCH signaling with γ-secretase or ADAM inhibitors in human cardiac …