[HTML][HTML] Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11β-hydroxysteroid dehydrogenase type 1 (HSD1) …
Z Michailidou, S Turban, E Miller, X Zou… - Journal of Biological …, 2012 - ASBMB
In obesity, rapidly expanding adipose tissue becomes hypoxic, precipitating inflammation,
fibrosis, and insulin resistance. Compensatory angiogenesis may prevent these events.
Mice lacking the intracellular glucocorticoid-amplifying enzyme 11β-hydroxysteroid
dehydrogenase type 1 (11βHSD1−/−) have" healthier" adipose tissue distribution and resist
metabolic disease with diet-induced obesity. Here we show that adipose tissues of
11βHSD1−/− mice exhibit attenuated hypoxia, induction of hypoxia-inducible factor (HIF-1α) …
fibrosis, and insulin resistance. Compensatory angiogenesis may prevent these events.
Mice lacking the intracellular glucocorticoid-amplifying enzyme 11β-hydroxysteroid
dehydrogenase type 1 (11βHSD1−/−) have" healthier" adipose tissue distribution and resist
metabolic disease with diet-induced obesity. Here we show that adipose tissues of
11βHSD1−/− mice exhibit attenuated hypoxia, induction of hypoxia-inducible factor (HIF-1α) …