[HTML][HTML] Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis

A Giordano, I Murano, E Mondini, J Perugini… - Journal of lipid …, 2013 - ASBMB
We previously suggested that, in obese animals and humans, white adipose tissue
inflammation results from the death of hypertrophic adipocytes; these are then cleared by
macrophages, giving rise to distinctive structures we denominated crown-like structures.
Here we present evidence that subcutaneous and visceral hypertrophic adipocytes of leptin-
deficient (ob/ob and db/db) obese mice exhibit ultrastructural abnormalities (including
calcium accumulation and cholesterol crystals), many of which are more common in …