Desferrioxamine suppresses experimental allergic encephalomyelitis induced by MBP in SJL mice

TV Pedchenko, SM LeVine - Journal of neuroimmunology, 1998 - Elsevier
Data from several studies indicate that free radicals have a pathogenic role in experimental
allergic encephalomyelitis (EAE). Iron can contribute to free radical damage by catalyzing
the formation of hydroxyl radical, inducing secondary initiation of lipid peroxidation and by
promoting the oxidation of proteins. The iron chelator, desferrioxamine, can limit these
oxidative reactions and it can scavenge peroxynitrite independent of iron chelation. Two
previous studies have examined the therapeutic value of desferrioxamine in EAE. One study …