Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants

R Guillet, BJ Stoll, CM Cotten, M Gantz… - …, 2006 - publications.aap.org
OBJECTIVE. We sought to determine if an association exists between the use of histamine-2
receptor (H2) blockers and the incidence of necrotizing enterocolitis (NEC) in infants of 401
to 1500 g in birth weight. STUDY DESIGN. Data from the National Institute of Child Health
and Human Development Neonatal Research Network very low birth weight (401–1500 g)
registry from September 1998 to December 2001 were analyzed. The relation between the
diagnosis of NEC (Bell stage II or greater) and antecedent H2-blocker treatment was …