[HTML][HTML] Surfactant protein-D regulates surfactant phospholipid homeostasis in vivo
TR Korfhagen, V Sheftelyevich, MS Burhans… - Journal of Biological …, 1998 - ASBMB
Surfactant protein D (SP-D) is a 43-kDa member of the collectin family of collagenous lectin
domain-containing proteins that is expressed in epithelial cells of the lung. The SP-D gene
was targeted by homologous recombination in embryonic stem cells that were used to
produce SP-D (±) and SP-D (−/−) mice. Both SP-D (−/−) and SP-D (±) mice survived
normally in the perinatal and postnatal periods. Whereas no abnormalities were observed in
SP-D (±) mice, alveolar and tissue phosphatidylcholine pool sizes were markedly increased …
domain-containing proteins that is expressed in epithelial cells of the lung. The SP-D gene
was targeted by homologous recombination in embryonic stem cells that were used to
produce SP-D (±) and SP-D (−/−) mice. Both SP-D (−/−) and SP-D (±) mice survived
normally in the perinatal and postnatal periods. Whereas no abnormalities were observed in
SP-D (±) mice, alveolar and tissue phosphatidylcholine pool sizes were markedly increased …