The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior
PA Randall, VK Vemuri, KN Segovia, EF Torres… - Pharmacology …, 2010 - Elsevier
Drugs that interfere with cannabinoid CB1 transmission suppress food-motivated behaviors,
and may be useful clinically as appetite suppressants. However, there may also be
undesirable side effects (eg, nausea, malaise, anxiety, and depression) that are produced
by the current generation of CB1 inverse agonists such as rimonabant and taranabant. For
that reason, it is important to continue research on novel cannabinoid antagonists. The
present studies examined the effects of the novel compound AM6545, which is a neutral …
and may be useful clinically as appetite suppressants. However, there may also be
undesirable side effects (eg, nausea, malaise, anxiety, and depression) that are produced
by the current generation of CB1 inverse agonists such as rimonabant and taranabant. For
that reason, it is important to continue research on novel cannabinoid antagonists. The
present studies examined the effects of the novel compound AM6545, which is a neutral …