Appetite suppression and weight loss after the cannabinoid antagonist SR 141716

G Colombo, R Agabio, G Diaz, C Lobina, R Reali… - Life sciences, 1998 - Elsevier
G Colombo, R Agabio, G Diaz, C Lobina, R Reali, GL Gessa
Life sciences, 1998Elsevier
The effect of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body
weight was assessed in adult, non-obese Wistar rats. The daily administration of SR 141716
(2.5 and 10 mg/kg; ip) reduced dose-dependently both food intake and body weight.
Tolerance to the anorectic effect developed within 5 days; in contrast, body weight in SR
141716-treated rats remained markedly below that of vehicle-treated rats throughout the
entire treatment period (14 days). The results suggest that brain cannabinoid receptors are …
The effect of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight was assessed in adult, non-obese Wistar rats. The daily administration of SR 141716 (2.5 and 10 mg/kg; i.p.) reduced dose-dependently both food intake and body weight. Tolerance to the anorectic effect developed within 5 days; in contrast, body weight in SR 141716-treated rats remained markedly below that of vehicle-treated rats throughout the entire treatment period (14 days). The results suggest that brain cannabinoid receptors are involved in the regulation of appetite and body weight.
Elsevier