Appetite suppression and weight loss after the cannabinoid antagonist SR 141716
The effect of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body
weight was assessed in adult, non-obese Wistar rats. The daily administration of SR 141716
(2.5 and 10 mg/kg; ip) reduced dose-dependently both food intake and body weight.
Tolerance to the anorectic effect developed within 5 days; in contrast, body weight in SR
141716-treated rats remained markedly below that of vehicle-treated rats throughout the
entire treatment period (14 days). The results suggest that brain cannabinoid receptors are …
weight was assessed in adult, non-obese Wistar rats. The daily administration of SR 141716
(2.5 and 10 mg/kg; ip) reduced dose-dependently both food intake and body weight.
Tolerance to the anorectic effect developed within 5 days; in contrast, body weight in SR
141716-treated rats remained markedly below that of vehicle-treated rats throughout the
entire treatment period (14 days). The results suggest that brain cannabinoid receptors are …
The effect of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight was assessed in adult, non-obese Wistar rats. The daily administration of SR 141716 (2.5 and 10 mg/kg; i.p.) reduced dose-dependently both food intake and body weight. Tolerance to the anorectic effect developed within 5 days; in contrast, body weight in SR 141716-treated rats remained markedly below that of vehicle-treated rats throughout the entire treatment period (14 days). The results suggest that brain cannabinoid receptors are involved in the regulation of appetite and body weight.
Elsevier