The anti-diabetic effects of GLP-1-gastrin dual agonist ZP3022 in ZDF rats
J Skarbaliene, T Secher, J Jelsing, TSR Neerup… - Peptides, 2015 - Elsevier
Aims/hypothesis Combination treatment with exendin-4 and gastrin has proven beneficial in
treatment of diabetes and preservation of beta cell mass in diabetic mice. Here, we
examined the chronic effects of a GLP-1-gastrin dual agonist ZP3022 on glycemic control
and beta cell dysfunction in overtly diabetic Zucker Diabetic Fatty (ZDF) rats. Methods ZDF
rats aged 11 weeks were dosed sc, bid for 8 weeks with vehicle, ZP3022, liraglutide,
exendin-4, or gastrin-17 with or without exendin-4. Glycemic control was assessed by …
treatment of diabetes and preservation of beta cell mass in diabetic mice. Here, we
examined the chronic effects of a GLP-1-gastrin dual agonist ZP3022 on glycemic control
and beta cell dysfunction in overtly diabetic Zucker Diabetic Fatty (ZDF) rats. Methods ZDF
rats aged 11 weeks were dosed sc, bid for 8 weeks with vehicle, ZP3022, liraglutide,
exendin-4, or gastrin-17 with or without exendin-4. Glycemic control was assessed by …
