Does gut hormone PYY3–36 decrease food intake in rodents?

M Tschöp, TR Castaneda, HG Joost, C Thöne-Reineke… - Nature, 2004 - nature.com
M Tschöp, TR Castaneda, HG Joost, C Thöne-Reineke, S Ortmann, S Klaus, MM Hagan…
Nature, 2004nature.com
Arising from: RL Batterham et al. Nature 418, 650–654 (2002); Batterham et al. reply
Batterham et al. report that the gut peptide hormone PYY3–36 decreases food intake and
body-weight gain in rodents, a discovery that has been heralded as potentially offering a
new therapy for obesity. However, we have been unable to replicate their results. Although
the reasons for this discrepancy remain undetermined, an effective anti-obesity drug
ultimately must produce its effects across a range of situations. The fact that the findings of …
Abstract
Arising from: R. L. Batterham et al. Nature418, 650–654 (2002); Batterham et al. reply
Batterham et al. report that the gut peptide hormone PYY3–36 decreases food intake and body-weight gain in rodents, a discovery that has been heralded as potentially offering a new therapy for obesity. However, we have been unable to replicate their results. Although the reasons for this discrepancy remain undetermined, an effective anti-obesity drug ultimately must produce its effects across a range of situations. The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3–36.
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