[HTML][HTML] NF-κB1 (p50) homodimers differentially regulate pro-and anti-inflammatory cytokines in macrophages

S Cao, X Zhang, JP Edwards, DM Mosser - Journal of Biological Chemistry, 2006 - ASBMB
NF-κB/Rel is a family of transcription factors whose activation has long been linked to the
production of inflammatory cytokines. Here, we studied NF-κB signaling in the regulation of
the anti-inflammatory cytokine, interleukin-10 (IL-10). We identified a role for a single NF-κB
family member, NF-κB1 (p50), in promoting the transcription of IL-10. The NF-κB ciselement
on IL-10 proximal promoter was located to–55/–46, where p50 can homodimerize and form
a complex with the transcriptional co-activator CREB-binding protein to activate …