Mediterranean diet and invasive breast cancer risk among women at high cardiovascular risk in the PREDIMED trial: a randomized clinical trial

E Toledo, J Salas-Salvadó, C Donat-Vargas… - JAMA internal …, 2015 - jamanetwork.com
Importance Breast cancer is the leading cause of female cancer burden, and its incidence
has increased by more than 20% worldwide since 2008. Some observational studies have
suggested that the Mediterranean diet may reduce the risk of breast cancer. Objective To
evaluate the effect of 2 interventions with Mediterranean diet vs the advice to follow a low-fat
diet (control) on breast cancer incidence. Design, Setting, and Participants The PREDIMED
study is a 1: 1: 1 randomized, single-blind, controlled field trial conducted at primary health …