[HTML][HTML] The role of AMPK and mTOR in nutrient sensing in pancreatic β-cells
CE Gleason, D Lu, LA Witters, CB Newgard… - Journal of Biological …, 2007 - ASBMB
The AMP-activated protein kinase (AMPK) is a central regulator of the energy status of the
cell, based on its unique ability to respond directly to fluctuations in the ratio of AMP: ATP.
Because glucose and amino acids stimulate insulin release from pancreatic β-cells by the
regulation of metabolic intermediates, AMPK represents an attractive candidate for control of
β-cell function. Here, we show that inhibition of AMPK in β-cells by high glucose inversely
correlates with activation of the mammalian Target of Rapamycin (mTOR) pathway, another …
cell, based on its unique ability to respond directly to fluctuations in the ratio of AMP: ATP.
Because glucose and amino acids stimulate insulin release from pancreatic β-cells by the
regulation of metabolic intermediates, AMPK represents an attractive candidate for control of
β-cell function. Here, we show that inhibition of AMPK in β-cells by high glucose inversely
correlates with activation of the mammalian Target of Rapamycin (mTOR) pathway, another …