The emerging role of B cells in tumor immunity

P Tsou, H Katayama, EJ Ostrin, SM Hanash - Cancer research, 2016 - AACR
Cancer research, 2016AACR
There is increasing evidence supporting a role for B cells in tumor immunology.
Paraneoplastic syndromes occurring before a cancer diagnosis have pointed to the potential
for harnessing the humoral immune response for early cancer detection. The presence of
tumor-infiltrating B lymphocytes has been linked to a favorable clinical outcome in many
types of cancers. However, B cells represent a heterogeneous population with functionally
distinct subsets, and the balance among subtypes impacts tumor development. Here, we …
Abstract
There is increasing evidence supporting a role for B cells in tumor immunology. Paraneoplastic syndromes occurring before a cancer diagnosis have pointed to the potential for harnessing the humoral immune response for early cancer detection. The presence of tumor-infiltrating B lymphocytes has been linked to a favorable clinical outcome in many types of cancers. However, B cells represent a heterogeneous population with functionally distinct subsets, and the balance among subtypes impacts tumor development. Here, we review recent findings related to B cells and to the humoral immune response in cancer and their translational significance. Cancer Res; 76(19); 5597–601. ©2016 AACR.
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