Molecular differences between subtypes of bone marrow adipocytes
Current molecular biology reports, 2018•Springer
Abstract Purpose of Review Bone marrow adipocytes (BMAs) have distinct molecular
properties and physiologic responses depending on their location within the skeleton.
Recent Findings This concept was introduced in the 1970s and validated more recently in
the contexts of cold exposure, sympathetic tone, hematopoiesis, diabetes, lactation, fasting,
and caloric restriction. Summary In this brief review, we discuss the concept of regulated vs
constitutive BMAs, explore their evolutionary and microenvironmental origins, define the site …
properties and physiologic responses depending on their location within the skeleton.
Recent Findings This concept was introduced in the 1970s and validated more recently in
the contexts of cold exposure, sympathetic tone, hematopoiesis, diabetes, lactation, fasting,
and caloric restriction. Summary In this brief review, we discuss the concept of regulated vs
constitutive BMAs, explore their evolutionary and microenvironmental origins, define the site …
Purpose of Review
Bone marrow adipocytes (BMAs) have distinct molecular properties and physiologic responses depending on their location within the skeleton.
Recent Findings
This concept was introduced in the 1970s and validated more recently in the contexts of cold exposure, sympathetic tone, hematopoiesis, diabetes, lactation, fasting, and caloric restriction.
Summary
In this brief review, we discuss the concept of regulated vs constitutive BMAs, explore their evolutionary and microenvironmental origins, define the site-specific molecular features of BMAs, and discuss the translational implications of the dual bone marrow adipose tissue hypothesis.
Springer