[HTML][HTML] Leptin at 14 y of age: an ongoing story

JM Friedman - The American journal of clinical nutrition, 2009 - Elsevier
The cloning of the ob gene and its gene product leptin has led to the elucidation of a robust
physiologic system that maintains constancy of fat stores. Leptin is a peptide hormone
secreted by adipose tissue and regulates adipose tissue mass and energy balance.
Recessive mutations in the leptin gene are associated with massive obesity in mice and in
some humans, which establishes a genetic basis for obesity. Leptin circulates in blood and
acts on the brain to regulate food intake and energy expenditure. When fat mass decreases …