[HTML][HTML] Bile acids modulate signaling by functional perturbation of plasma membrane domains

Y Zhou, KN Maxwell, E Sezgin, M Lu, H Liang… - Journal of Biological …, 2013 - ASBMB
Eukaryotic cell membranes are organized into functional lipid and protein domains, the most
widely studied being membrane rafts. Although rafts have been associated with numerous
plasma membrane functions, the mechanisms by which these domains themselves are
regulated remain undefined. Bile acids (BAs), whose primary function is the solubilization of
dietary lipids for digestion and absorption, can affect cells by interacting directly with
membranes. To investigate whether these interactions affected domain organization in …